Go or stop? Divergent roles of Reelin in radial neuronal migration.
نویسندگان
چکیده
Neuronal migration is an essential step of brain development and is controlled by a variety of cellular proteins and extracellular matrix molecules. Reelin, an extracellular matrix protein, is required for neuronal migration. Over the past 10 years, the Reelin signaling cascade has been studied intensively. However, the role of Reelin in neuronal migration has remained unclear. Different Reelin fragments and different Reelin receptors suggest multiple functions of Reelin. In this review, the authors focus on Reelin effects on the actin cytoskeleton of migrating neurons.
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ورودعنوان ژورنال:
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
دوره 16 4 شماره
صفحات -
تاریخ انتشار 2010